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Dysregulated microRNA (miRNA) levels in USB1 mutants during blood development contribute to hematopoietic failure, because of a failure to remove 3\u2032-end adenylated tails added by PAPD5\/7. Modulation of miRNA 3\u2032-end adenylation through genetic or chemical inhibition of PAPD5\/7 rescues hematopoiesis in USB1 mutants. This work shows that USB1 acts as a miRNA deadenylase and suggests PAPD5\/7 inhibition as a potential therapy for PN.<\/jats:p>","DOI":"10.1126\/science.abj8379","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T18:58:15Z","timestamp":1677783495000},"page":"901-907","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":42,"title":["USB1 is a miRNA deadenylase that regulates hematopoietic development"],"prefix":"10.1126","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-8314","authenticated-orcid":true,"given":"Ho-Chang","family":"Jeong","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA."},{"name":"Center for Genome Integrity, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, 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