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Using a massively parallel assay for m\n                    <jats:sup>6<\/jats:sup>\n                    A (MPm\n                    <jats:sup>6<\/jats:sup>\n                    A), we discover that m\n                    <jats:sup>6<\/jats:sup>\n                    A specificity is globally regulated by suppressors that prevent m\n                    <jats:sup>6<\/jats:sup>\n                    A deposition in unmethylated transcriptome regions. We identify exon junction complexes (EJCs) as m\n                    <jats:sup>6<\/jats:sup>\n                    A suppressors that protect exon junction\u2013proximal RNA within coding sequences from methylation and regulate mRNA stability through m\n                    <jats:sup>6<\/jats:sup>\n                    A suppression. EJC suppression of m\n                    <jats:sup>6<\/jats:sup>\n                    A underlies multiple global characteristics of mRNA m\n                    <jats:sup>6<\/jats:sup>\n                    A specificity, with the local range of EJC protection sufficient to suppress m\n                    <jats:sup>6<\/jats:sup>\n                    A deposition in average-length internal exons but not in long internal and terminal exons. EJC-suppressed methylation sites colocalize with EJC-suppressed splice sites, which suggests that exon architecture broadly determines local mRNA accessibility to regulatory complexes.\n                  <\/jats:p>","DOI":"10.1126\/science.abj9090","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T09:24:40Z","timestamp":1674811480000},"page":"677-682","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":231,"title":["Exon architecture controls mRNA m\n                    <sup>6<\/sup>\n                    A suppression and gene expression"],"prefix":"10.1126","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-810X","authenticated-orcid":true,"given":"P. 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