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We demonstrate that by using supported gold-palladium (AuPd) alloyed nanoparticles in conjunction with a titanium silicate-1 (TS-1) catalyst, H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    can be generated in situ as needed, producing cyclohexanone oxime with &gt;95% selectivity, comparable to the current industrial route. The ammoximation of several additional simple ketones is also demonstrated. Our approach eliminates the need to transport and store highly concentrated, stabilized H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , potentially achieving substantial environmental and economic savings. This approach could form the basis of an alternative route to numerous chemical transformations that are currently dependent on a combination of preformed H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and TS-1, while allowing for considerable process intensification.\n                  <\/jats:p>","DOI":"10.1126\/science.abl4822","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T13:57:36Z","timestamp":1651759056000},"page":"615-620","source":"Crossref","is-referenced-by-count":293,"title":["Highly efficient catalytic production of oximes from ketones using in situ\u2013generated H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>"],"prefix":"10.1126","volume":"376","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9990-7064","authenticated-orcid":true,"given":"Richard J.","family":"Lewis","sequence":"first","affiliation":[{"name":"Max Planck\u2013Cardiff Centre on the Fundamentals of Heterogeneous Catalysis FUNCAT, Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ueura","sequence":"additional","affiliation":[{"name":"UBE Corporation, 1978-5, Kogushi, Ube, Yamaguchi 755-8633, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-0774","authenticated-orcid":true,"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical, In-situ Centre for Physical Sciences, Shanghai Jiao Tong University, Shanghai 200240, P.R. 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