{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:18:59Z","timestamp":1792513139639,"version":"4.5.0"},"reference-count":34,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6571","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,11,26]]},"abstract":"<jats:title>Disease and hippocampal dysfunction<\/jats:title>\n          <jats:p>\n            Impaired function of the brain\u2019s hippocampus can underpin psychiatric symptoms and cognitive impairment. Looking at postmortem brain samples from patients affected by any of several neurodegenerative disorders, Terreros-Roncal\n            <jats:italic>et al<\/jats:italic>\n            . investigated whether adult neurogenesis was disrupted (see the Perspective by Gage). Indeed, functions of the neurogenic niche shifted and the cells produced were abnormal in shape and differentiation. The neuronal plasticity characteristic of the hippocampus may make it especially susceptible to the ravages of neurodegenerative disease. \u2014PJH\n          <\/jats:p>","DOI":"10.1126\/science.abl5163","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T03:58:45Z","timestamp":1634875125000},"page":"1106-1113","source":"Crossref","is-referenced-by-count":283,"title":["Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"],"prefix":"10.1126","volume":"374","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-6368","authenticated-orcid":true,"given":"J.","family":"Terreros-Roncal","sequence":"first","affiliation":[{"name":"Department of Molecular Neuropathology, Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CBMSO), Spanish Research Council (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), Madrid, Spain."},{"name":"Department of Molecular Biology, Faculty of Sciences, Universidad Aut\u00f3noma de Madrid, Madrid, Spain."},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-4875","authenticated-orcid":true,"given":"E. 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