{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:35:26Z","timestamp":1793946926653,"version":"4.8.0"},"reference-count":67,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6575","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,12,24]]},"abstract":"<jats:title>Fibrin gums up the works<\/jats:title>\n                  <jats:p>\n                    Plasmin is an abundant plasma protease that cleaves and deactivates the clot-associated protein fibrin. Human deficiencies in plasmin and its inactive proenzyme form, plasminogen (PLG), cause severe inflammation in mucosal tissues such as the mouth and eyes. Silva\n                    <jats:italic>et al<\/jats:italic>\n                    . report that, like humans, mice lacking plasminogen accumulate extravascular fibrin and develop an oral pathology that phenocopies human ligneous periodontitis (see the Perspective by Vicanolo and Hidalgo). The excess fibrin activates neutrophils through the \u03b1M\u03b22 (Mac-1) integrin receptor, which triggers the production of reactive oxygen species and neutrophil extracellular traps. Additionally, certain human polymorphisms in the PLG gene were found to be associated with increased likelihood of developing periodontitis, suggesting that fibrin\u2013neutrophil interactions may be an attractive target for future treatments of this prevalent disease. \u2014STS\n                  <\/jats:p>","DOI":"10.1126\/science.abl5450","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T13:55:56Z","timestamp":1640267756000},"source":"Crossref","is-referenced-by-count":184,"title":["Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier"],"prefix":"10.1126","volume":"374","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-2657","authenticated-orcid":true,"given":"Lakmali M.","family":"Silva","sequence":"first","affiliation":[{"name":"Proteases and Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA."},{"name":"Oral Immunity 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