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Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury\u2013induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.<\/jats:p>","DOI":"10.1126\/science.abl6773","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T13:58:15Z","timestamp":1653573495000},"page":"80-86","source":"Crossref","is-referenced-by-count":206,"title":["Microglia-mediated degradation of perineuronal nets promotes pain"],"prefix":"10.1126","volume":"377","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2387-3800","authenticated-orcid":true,"given":"Shannon","family":"Tansley","sequence":"first","affiliation":[{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada."},{"name":"Department of Psychology, Faculty of Science, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-0691","authenticated-orcid":true,"given":"Ning","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba Ure\u00f1a","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-3035","authenticated-orcid":true,"given":"Calvin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-3928","authenticated-orcid":true,"given":"Kevin C.","family":"Lister","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6128-9694","authenticated-orcid":true,"given":"Einer","family":"Mu\u00f1oz-Pino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6787-1781","authenticated-orcid":true,"given":"Noosha","family":"Yousefpour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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