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In this Review, we retrace our steps through the questions that this community faced as the pandemic unfolded. We focus on the key roles that mathematical modeling and quantitative analyses of empirical data have played in allowing us to address these questions and ultimately to better understand and control the pandemic.<\/jats:p>","DOI":"10.1126\/science.abm4915","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T18:59:54Z","timestamp":1646938794000},"page":"1116-1121","source":"Crossref","is-referenced-by-count":293,"title":["The changing epidemiology of SARS-CoV-2"],"prefix":"10.1126","volume":"375","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-6141","authenticated-orcid":true,"given":"Katia","family":"Koelle","sequence":"first","affiliation":[{"name":"Department of Biology, O. 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