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Activation of astrocytic IDO1 by amyloid \u03b2 and tau oligomers increases KYN and suppresses glycolysis in an aryl hydrocarbon receptor\u2013dependent manner. In amyloid and tau models, IDO1 inhibition improves hippocampal glucose metabolism and rescues hippocampal long-term potentiation in a monocarboxylate transporter\u2013dependent manner. In astrocytic and neuronal cocultures from AD subjects, IDO1 inhibition improved astrocytic production of lactate and uptake by neurons. 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