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This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type\u2013specific and synapse type\u2013specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV\n                    <jats:sup>+<\/jats:sup>\n                    interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system.\n                  <\/jats:p>","DOI":"10.1126\/science.abm7466","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T14:21:06Z","timestamp":1669299666000},"source":"Crossref","is-referenced-by-count":81,"title":["Cortical wiring by synapse type\u2013specific control of local protein synthesis"],"prefix":"10.1126","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-7738","authenticated-orcid":true,"given":"Cl\u00e9mence","family":"Bernard","sequence":"first","affiliation":[{"name":"Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London SE1 1UL, UK."},{"name":"MRC Centre for Neurodevelopmental Disorders, King\u2019s College London, London SE1 1UL, 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