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We identified adenosine 5\u2032-sulfamate as a broad-specificity compound that hijacks a range of aaRSs and ML901 as a specific reagent that hijacks a single aaRS in the malaria parasite\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    , namely tyrosine RS (\n                    <jats:italic>Pf<\/jats:italic>\n                    YRS). ML901 exerts whole-life-cycle\u2013killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray crystallographic studies of plasmodium and human YRSs reveal differential flexibility of a loop over the catalytic site that underpins differential susceptibility to reaction hijacking by ML901.\n                  <\/jats:p>","DOI":"10.1126\/science.abn0611","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T13:58:33Z","timestamp":1654178313000},"page":"1074-1079","source":"Crossref","is-referenced-by-count":54,"title":["Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy"],"prefix":"10.1126","volume":"376","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-4677","authenticated-orcid":true,"given":"Stanley C.","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, 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