{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:46:19Z","timestamp":1794008779491,"version":"4.8.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6603","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,7,15]]},"abstract":"<jats:p>Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function. Cardiac macrophages lacking the Y chromosome exhibited polarization toward a more fibrotic phenotype, and treatment with a transforming growth factor \u03b21\u2013neutralizing antibody ameliorated cardiac dysfunction in mLOY mice. A prospective study revealed that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure\u2013associated mortality. Together, these results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men.<\/jats:p>","DOI":"10.1126\/science.abn3100","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T13:56:26Z","timestamp":1657806986000},"page":"292-297","source":"Crossref","is-referenced-by-count":279,"title":["Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality"],"prefix":"10.1126","volume":"377","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3361-0839","authenticated-orcid":true,"given":"Soichi","family":"Sano","sequence":"first","affiliation":[{"name":"Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."},{"name":"Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Horitani","sequence":"additional","affiliation":[{"name":"Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-4230","authenticated-orcid":true,"given":"Hayato","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Hematovascular Biology Center, Robert M. 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