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Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland\u2013innervating neurons. Depletion of macrophages in the SCG prevented disease-associated denervation of the pineal gland and restored physiological melatonin secretion. Our data identify the mechanism by which diurnal rhythmicity in cardiac disease is disturbed and suggest a target for therapeutic intervention.<\/jats:p>","DOI":"10.1126\/science.abn6366","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T18:27:48Z","timestamp":1689877668000},"page":"285-290","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":88,"title":["Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease"],"prefix":"10.1126","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9364-3349","authenticated-orcid":true,"given":"Karin A.","family":"Ziegler","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ahles","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-6327","authenticated-orcid":true,"given":"Anne","family":"Dueck","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-1461","authenticated-orcid":true,"given":"Dena","family":"Esfandyari","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-2270","authenticated-orcid":true,"given":"Pauline","family":"Pichler","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9195-5579","authenticated-orcid":true,"given":"Karolin","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-6291","authenticated-orcid":true,"given":"Stefan","family":"Kotschi","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t (LMU) M\u00fcnchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-3991","authenticated-orcid":true,"given":"Alexander","family":"Bartelt","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany."},{"name":"Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t (LMU) M\u00fcnchen, Munich, Germany."},{"name":"Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany."},{"name":"Department of Molecular Metabolism &amp; Sabri \u00dclker Center for Metabolic Research, Harvard. 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