{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:47:05Z","timestamp":1790794025851,"version":"4.1.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6584","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,3,4]]},"abstract":"<jats:p>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant infective strain. We report the structures of the Omicron spike trimer on its own and in complex with angiotensin-converting enzyme 2 (ACE2) or an anti-Omicron antibody. Most Omicron mutations are located on the surface of the spike protein and change binding epitopes to many current antibodies. In the ACE2-binding site, compensating mutations strengthen receptor binding domain (RBD) binding to ACE2. Both the RBD and the apo form of the Omicron spike trimer are thermodynamically unstable. An unusual RBD-RBD interaction in the ACE2-spike complex supports the open conformation and further reinforces ACE2 binding to the spike trimer. A broad-spectrum therapeutic antibody, JMB2002, which has completed a phase 1 clinical trial, maintains neutralizing activity against Omicron. JMB2002 binds to RBD differently from other characterized antibodies and inhibits ACE2 binding.<\/jats:p>","DOI":"10.1126\/science.abn8863","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T10:01:12Z","timestamp":1644314472000},"page":"1048-1053","source":"Crossref","is-referenced-by-count":285,"title":["Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody"],"prefix":"10.1126","volume":"375","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-4907","authenticated-orcid":true,"given":"Wanchao","family":"Yin","sequence":"first","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-7511","authenticated-orcid":true,"given":"Youwei","family":"Xu","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-4037","authenticated-orcid":true,"given":"Peiyu","family":"Xu","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-4805","authenticated-orcid":true,"given":"Xiaodan","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-3838","authenticated-orcid":true,"given":"Canrong","family":"Wu","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-7411","authenticated-orcid":true,"given":"Chunyin","family":"Gu","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-5480","authenticated-orcid":true,"given":"Xinheng","family":"He","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4274-5698","authenticated-orcid":true,"given":"Xiaoxi","family":"Wang","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5653-0260","authenticated-orcid":true,"given":"Sijie","family":"Huang","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingning","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Shanghai Advanced Electron Microscope Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wu","sequence":"additional","affiliation":[{"name":"The Shanghai Advanced Electron Microscope Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[{"name":"The Shanghai Advanced Electron Microscope Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-4590","authenticated-orcid":true,"given":"Zifu","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-2934","authenticated-orcid":true,"given":"Zongda","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Jia","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1336-8790","authenticated-orcid":true,"given":"Kaiwen","family":"Xia","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-8714","authenticated-orcid":true,"given":"Xueping","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-5839","authenticated-orcid":true,"given":"Bin","family":"Song","sequence":"additional","affiliation":[{"name":"Immunological Disease Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7932-5753","authenticated-orcid":true,"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Immunological Disease Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-6315","authenticated-orcid":true,"given":"Hualiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."},{"name":"School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-3750","authenticated-orcid":true,"given":"Xi","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-1413","authenticated-orcid":true,"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-0644","authenticated-orcid":true,"given":"Su-Jun","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6829-8144","authenticated-orcid":true,"given":"H. Eric","family":"Xu","sequence":"additional","affiliation":[{"name":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."},{"name":"School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.2022440"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh1139"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi9745"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","unstructured":"R. Earnest R. Uddin N. Matluk N. Renzette K. J. Siddle C. Loreth G. Adams C. H. Tomkins-Tinch M. E. Petrone J. E. Rothman M. I. Breban R. T. Koch K. Billig J. R. Fauver C. B. F. Vogels S. Turbett K. Bilguvar B. De Kumar M. L. Landry D. R. Peaper K. Kelly G. Omerza H. Grieser S. Meak J. Martha H. H. Dewey S. Kales D. Berenzy K. Carpenter-Azevedo E. King R. C. Huard S. C. Smole C. M. Brown T. Fink A. S. Lang G. R. Gallagher P. C. Sabeti S. Gabriel B. L. MacInnis New England Variant Investigation Team R. Tewhey M. D. Adams D. J. Park J. E. Lemieux N. D. Grubaugh Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England USA. medRxiv 2021.10.06.21264641 [Preprint] (2021). https:\/\/doi.org\/10.1101\/2021.10.06.21264641.","DOI":"10.1101\/2021.10.06.21264641"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01548-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04385-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04389-z"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04388-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0826"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04386-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20321-x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6952"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0827"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf1906"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2349-y"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.045"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2180-5"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd3255"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2021.1930636"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe7565"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009885"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4193"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2015.08.008"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42166"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4169"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02399-1"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg520"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.11.004"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0909049503024130"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798318002425"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3943"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08613"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.abn8863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T19:36:39Z","timestamp":1705347399000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.abn8863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":36,"journal-issue":{"issue":"6584","published-print":{"date-parts":[[2022,3,4]]}},"alternative-id":["10.1126\/science.abn8863"],"URL":"https:\/\/doi.org\/10.1126\/science.abn8863","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,4]]}}}