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The resultant DCM and ACM ventricular cell atlas demonstrated distinct right and left ventricular responses, highlighting genotype-associated pathways, intercellular interactions, and differential gene expression at single-cell resolution. Together, these data illuminate both shared and distinct cellular and molecular architectures of human heart failure and suggest candidate therapeutic targets.<\/jats:p>","DOI":"10.1126\/science.abo1984","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T13:58:22Z","timestamp":1659621502000},"source":"Crossref","is-referenced-by-count":236,"title":["Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies"],"prefix":"10.1126","volume":"377","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8559-5888","authenticated-orcid":true,"given":"Daniel","family":"Reichart","sequence":"first","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Medicine I, University Hospital, LMU Munich, 80336 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-433X","authenticated-orcid":true,"given":"Eric L.","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Sciences, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-6272","authenticated-orcid":true,"given":"Henrike","family":"Maatz","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Sciences, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio M. 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