{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:45:06Z","timestamp":1792205106870,"version":"4.4.0"},"reference-count":83,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6649","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2023,6,9]]},"abstract":"<jats:p>\n                    Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects remain unknown. By inducing the down-regulation of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in the ileum, post-ABX gut recolonization by\n                    <jats:italic>Enterocloster<\/jats:italic>\n                    species drove the emigration of enterotropic \u03b14\u03b27\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T 17 cells into the tumor. These deleterious ABX effects were mimicked by oral gavage of\n                    <jats:italic>Enterocloster<\/jats:italic>\n                    species, by genetic deficiency, or by antibody-mediated neutralization of MAdCAM-1 and its receptor, \u03b14\u03b27 integrin. By contrast, fecal microbiota transplantation or interleukin-17A neutralization prevented ABX-induced immunosuppression. In independent lung, kidney, and bladder cancer patient cohorts, low serum levels of soluble MAdCAM-1 had a negative prognostic impact. Thus, the MAdCAM-1\u2013\u03b14\u03b27 axis constitutes an actionable gut immune checkpoint in cancer immunosurveillance.\n                  <\/jats:p>","DOI":"10.1126\/science.abo2296","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T13:58:45Z","timestamp":1686232725000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":240,"title":["A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers"],"prefix":"10.1126","volume":"380","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-9688","authenticated-orcid":true,"given":"Marine","family":"Fidelle","sequence":"first","affiliation":[{"name":"Gustave Roussy Cancer Campus, Villejuif Cedex, France."},{"name":"Universit\u00e9 Paris-Saclay, Facult\u00e9 de M\u00e9decine, Le Kremlin-Bic\u00eatre, France."},{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM) U1015, \u00c9quipe Labellis\u00e9e - Ligue Nationale contre le Cancer, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-8426","authenticated-orcid":true,"given":"Conrad","family":"Rauber","sequence":"additional","affiliation":[{"name":"Gustave Roussy Cancer Campus, Villejuif Cedex, France."},{"name":"Universit\u00e9 Paris-Saclay, Facult\u00e9 de M\u00e9decine, Le Kremlin-Bic\u00eatre, France."},{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM) U1015, \u00c9quipe Labellis\u00e9e - Ligue Nationale contre le Cancer, Villejuif, France."},{"name":"Department of Gastroenterology and Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-142X","authenticated-orcid":true,"given":"Carolina","family":"Alves Costa Silva","sequence":"additional","affiliation":[{"name":"Gustave Roussy Cancer 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