{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:17:02Z","timestamp":1790695022298,"version":"4.1.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6611","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"<jats:p>\n            Parasites impose fitness costs on their hosts. Biologists often assume that natural selection favors infection-resistant hosts. Yet, when the immune response itself is costly, theory suggests that selection may sometimes favor loss of resistance, which may result in alternative stable states where some populations are resistant and others are tolerant. Intraspecific variation in immune costs is rarely surveyed in a manner that tests evolutionary patterns, and there are few examples of adaptive loss of resistance. Here, we show that when marine threespine stickleback colonized freshwater lakes, they gained resistance to the freshwater-associated cestode\n            <jats:italic>Schistocephalus solidus<\/jats:italic>\n            . Extensive peritoneal fibrosis and inflammation are a commonly observed phenotype that contributes to suppression of cestode growth and viability but also imposes a substantial cost on fecundity. Combining genetic mapping and population genomics, we find that opposing selection generates immune system differences between tolerant and resistant populations, consistent with divergent optimization.\n          <\/jats:p>","DOI":"10.1126\/science.abo3411","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T17:57:40Z","timestamp":1662659860000},"page":"1206-1211","source":"Crossref","is-referenced-by-count":73,"title":["Evolutionary gain and loss of a pathological immune response to parasitism"],"prefix":"10.1126","volume":"377","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4839-6684","authenticated-orcid":true,"given":"Jesse N.","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7585-8402","authenticated-orcid":true,"given":"Natalie C.","family":"Steinel","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-7753","authenticated-orcid":true,"given":"Foen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kum Chuan","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Lohman","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-7326","authenticated-orcid":true,"given":"Lauren E.","family":"Fuess","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-1717","authenticated-orcid":true,"given":"Swapna","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9587-8665","authenticated-orcid":true,"given":"Stephen P. 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