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Mass spectrometry\u2013based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE.<\/jats:p>","DOI":"10.1126\/science.abo5044","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T13:59:20Z","timestamp":1681394360000},"page":"178-187","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":79,"title":["Immobility-associated thromboprotection is conserved across mammalian species from bear to human"],"prefix":"10.1126","volume":"380","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-5807","authenticated-orcid":true,"given":"Manuela","family":"Thienel","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, 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