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FA reacts with privileged, hyperreactive cysteine sites in the proteome, including Cys120 in S-adenosylmethionine synthase isoform type-1 (MAT1A). FA exposure inhibited MAT1A activity and decreased SAM production with MAT-isoform specificity. A genetic mouse model of chronic FA overload showed a decrease n SAM and in methylation on selected histones and genes. Epigenetic and transcriptional regulation of\n                    <jats:italic>Mat1a<\/jats:italic>\n                    and related genes function as compensatory mechanisms for FA-dependent SAM depletion, revealing a biochemical feedback cycle between FA and SAM one-carbon units.\n                  <\/jats:p>","DOI":"10.1126\/science.abp9201","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T14:00:04Z","timestamp":1698933604000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":92,"title":["Formaldehyde regulates\n                    <i>S<\/i>\n                    -adenosylmethionine biosynthesis and one-carbon metabolism"],"prefix":"10.1126","volume":"382","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-9332","authenticated-orcid":true,"given":"Vanha N.","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-5615","authenticated-orcid":true,"given":"Kevin J.","family":"Bruemmer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D. 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