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The long noncoding RNA\n                    <jats:italic>MEG3<\/jats:italic>\n                    was strongly up-regulated in human neurons\n                    <jats:italic>.<\/jats:italic>\n                    This neuron-specific long noncoding RNA is also up-regulated in AD patients.\n                    <jats:italic>MEG3<\/jats:italic>\n                    expression alone was sufficient to induce necroptosis in human neurons in vitro. Down-regulation of\n                    <jats:italic>MEG3<\/jats:italic>\n                    and inhibition of necroptosis using pharmacological or genetic manipulation of receptor-interacting protein kinase 1 (RIPK1), RIPK3, or mixed lineage kinase domain-like protein (MLKL) rescued neuronal cell loss in xenografted human neurons. This model suggests potential therapeutic approaches for AD and reveals a human-specific vulnerability to AD.\n                  <\/jats:p>","DOI":"10.1126\/science.abp9556","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:58:58Z","timestamp":1694699938000},"page":"1176-1182","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":236,"title":["MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer\u2019s disease"],"prefix":"10.1126","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-0577","authenticated-orcid":true,"given":"Sriram","family":"Balusu","sequence":"first","affiliation":[{"name":"VIB-KU Leuven Center for Brain and Disease Research, 3000 Leuven, Belgium."},{"name":"Leuven Brain Institute, KU Leuven, 3000 Leuven, 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