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Combining hypertension, obesity, and mitral valve regurgitation (HOMER) in mice elicited enlarged, fibrosed, and fibrillation-prone atria. Single-cell transcriptomes from HOMER mouse atria recapitulated cell composition and transcriptome changes observed in patients. Inhibiting monocyte migration reduced arrhythmia in\n            <jats:italic>Ccr2<\/jats:italic>\n            <jats:sup>\u2212\u2215\u2212<\/jats:sup>\n            HOMER mice. Cell-cell interaction analysis identified SPP1 as a pleiotropic signal that promotes atrial fibrillation through cross-talk with local immune and stromal cells. Deleting\n            <jats:italic>Spp1<\/jats:italic>\n            reduced atrial fibrillation in HOMER mice. These results identify SPP1\n            <jats:sup>+<\/jats:sup>\n            macrophages as targets for immunotherapy in atrial fibrillation.\n          <\/jats:p>","DOI":"10.1126\/science.abq3061","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T17:55:32Z","timestamp":1689270932000},"page":"231-239","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":241,"title":["Recruited macrophages elicit atrial fibrillation"],"prefix":"10.1126","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-658X","authenticated-orcid":true,"given":"Maarten","family":"Hulsmans","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 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