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COV44-62 and COV44-79 broadly neutralize alpha- and betacoronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants BA.2 and BA.4\/5, albeit with lower potency than receptor binding domain\u2013specific antibodies. In crystal structures of COV44-62 and COV44-79 antigen-binding fragments with the SARS-CoV-2 fusion peptide, the fusion peptide epitope adopts a helical structure and includes the arginine residue at the S2\u2032 cleavage site. COV44-79 limited disease caused by SARS-CoV-2 in a Syrian hamster model. These findings highlight the fusion peptide as a candidate epitope for next-generation coronavirus vaccine development.<\/jats:p>","DOI":"10.1126\/science.abq3773","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T09:59:14Z","timestamp":1657619954000},"page":"728-735","source":"Crossref","is-referenced-by-count":268,"title":["Broadly neutralizing antibodies target the coronavirus fusion peptide"],"prefix":"10.1126","volume":"377","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-2740","authenticated-orcid":true,"given":"Cherrelle","family":"Dacon","sequence":"first","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, 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