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CRISPR\/Cas9\u2013mediated reduction of candidate genes reduced astrocyte morphological complexity and resulted in cognitive deficits. The same genes were down-regulated in human AD, in an AD mouse model that displayed reduced astrocyte morphology, and in other human brain disorders. We thus provide comprehensive molecular data on astrocyte diversity and mechanisms across the CNS and on the molecular basis of astrocyte morphology in health and disease.<\/jats:p>","DOI":"10.1126\/science.adc9020","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T13:58:37Z","timestamp":1667483917000},"source":"Crossref","is-referenced-by-count":581,"title":["Molecular basis of astrocyte diversity and morphology across the CNS in health and disease"],"prefix":"10.1126","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-6707","authenticated-orcid":true,"given":"Fumito","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Physiology, University of California Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-3078","authenticated-orcid":true,"given":"Atsushi","family":"Kasai","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-9091","authenticated-orcid":true,"given":"Joselyn S.","family":"Soto","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of California Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-0110","authenticated-orcid":true,"given":"Xinzhu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of California Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Qu","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-4016","authenticated-orcid":true,"given":"Hitoshi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan."},{"name":"Molecular Research Center for Children\u2019s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan."},{"name":"Division of Bioscience, Institute for Datability Science, Osaka University, Suita, Osaka, Japan."},{"name":"Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan."},{"name":"Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-348X","authenticated-orcid":true,"given":"Viviana","family":"Gradinaru","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-1218","authenticated-orcid":true,"given":"Baljit S.","family":"Khakh","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of California Los Angeles, Los Angeles, CA, USA."},{"name":"Department of Neurobiology, University of California Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","unstructured":"C. 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