{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:19:10Z","timestamp":1791033550145,"version":"4.1.0"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6619","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,11,4]]},"abstract":"<jats:p>\n                    Male and female unisexual flowers evolved from hermaphroditic ancestors, and control of flower sex is useful for plant breeding. We isolated a female-to-male sex transition mutant in melon and identified the causal gene as the carpel identity gene\n                    <jats:italic>CRABS CLAW (CRC)<\/jats:italic>\n                    . We show that the master regulator of sex determination in cucurbits, the transcription factor\n                    <jats:italic>WIP1<\/jats:italic>\n                    whose expression orchestrates male flower development, recruits the corepressor TOPLESS to the\n                    <jats:italic>CRC<\/jats:italic>\n                    promoter to suppress its expression through histone deacetylation. Impairing TOPLESS-WIP1 physical interaction leads to\n                    <jats:italic>CRC<\/jats:italic>\n                    expression, carpel determination, and consequently the expression of the stamina inhibitor, the aminocyclopropane-1-carboxylic acid synthase 7 (\n                    <jats:italic>CmACS7<\/jats:italic>\n                    ), leading to female flower development. Our findings suggest that sex genes evolved to interfere with flower meristematic function, leading to unisexual flower development.\n                  <\/jats:p>","DOI":"10.1126\/science.add4250","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T13:58:37Z","timestamp":1667483917000},"page":"543-549","source":"Crossref","is-referenced-by-count":84,"title":["<b>The control of carpel determinacy pathway leads to sex determination<\/b>\n                    <b>in cucurbits<\/b>"],"prefix":"10.1126","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-6056","authenticated-orcid":true,"given":"Siqi","family":"Zhang","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, INRAE, Universit\u00e9 Evry, Institute of Plant Sciences Paris-Saclay (IPS2); 91190 Gif sur Yvette, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-864X","authenticated-orcid":true,"given":"Feng-Quan","family":"Tan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, INRAE, Universit\u00e9 Evry, Institute of Plant Sciences Paris-Saclay (IPS2); 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