{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:50:27Z","timestamp":1792799427745,"version":"4.5.0"},"reference-count":116,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6623","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:p>\n                    Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine\u2013priming candidate eOD-GT8 60mer adjuvanted with AS01\n                    <jats:sub>B<\/jats:sub>\n                    had a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.\n                  <\/jats:p>","DOI":"10.1126\/science.add6502","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T14:05:55Z","timestamp":1669903555000},"source":"Crossref","is-referenced-by-count":306,"title":["Vaccination induces HIV broadly neutralizing antibody precursors in humans"],"prefix":"10.1126","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-7170","authenticated-orcid":true,"given":"David J.","family":"Leggat","sequence":"first","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, 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