{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:55:02Z","timestamp":1792652102312,"version":"4.5.0"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6670","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:p>\n            Sex determination in mammals depends on the differentiation of the supporting lineage of the gonads into Sertoli or pregranulosa cells that govern testis and ovary development, respectively. Although the Y-linked testis-determining gene\n            <jats:italic>Sry<\/jats:italic>\n            has been identified, the ovarian-determining factor remains unknown. In this study, we identified \u2212KTS, a major, alternatively spliced isoform of the Wilms tumor suppressor WT1, as a key determinant of female sex determination. Loss of \u2212\n            <jats:italic>KTS<\/jats:italic>\n            variants blocked gonadal differentiation in mice, whereas increased expression, as found in Frasier syndrome, induced precocious differentiation of ovaries independently of their genetic sex. In XY embryos, this antagonized\n            <jats:italic>Sry<\/jats:italic>\n            expression, resulting in male-to-female sex reversal. Our results identify \u2212KTS as an ovarian-determining factor and demonstrate that its time of activation is critical in gonadal sex differentiation.\n          <\/jats:p>","DOI":"10.1126\/science.add8831","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T18:00:04Z","timestamp":1698948004000},"page":"600-606","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":61,"title":["The\n            <i>\u2212KTS<\/i>\n            splice variant of WT1 is essential for ovarian determination in mice"],"prefix":"10.1126","volume":"382","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-4754","authenticated-orcid":true,"given":"Elodie P.","family":"Gregoire","sequence":"first","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, INSERM, CNRS, Institut de Biologie Valrose (iBV), 06108 Nice, 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