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We prepared several important classes of \u03b1,\u03b2-chiral tertiary alcohols in a single step with high levels of diastereo- and enantioselectivity through a dynamic kinetic asymmetric addition of aryl and alkenyl nucleophiles. We applied this protocol to modify several profen drugs and to rapidly synthesize biologically relevant molecules. We expect this nickel-catalyzed, base-free ketone racemization process to be a widely applicable strategy for the development of dynamic kinetic processes.<\/jats:p>","DOI":"10.1126\/science.ade0760","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T18:58:21Z","timestamp":1676573901000},"page":"662-670","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":81,"title":["Dynamic kinetic asymmetric arylation and alkenylation of ketones"],"prefix":"10.1126","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1831-3147","authenticated-orcid":true,"given":"Lin-Xin","family":"Ruan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1684-2566","authenticated-orcid":true,"given":"Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-6824","authenticated-orcid":true,"given":"Shi-Liang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"E. 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