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We describe the properties of a naturally occurring, non\u2013genetically modified symbiotic bacterium,\n            <jats:italic>Delftia tsuruhatensis<\/jats:italic>\n            TC1, which was isolated from mosquitoes incapable of sustaining the development of\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            parasites.\n            <jats:italic>D. tsuruhatensis<\/jats:italic>\n            TC1 inhibits early stages of\n            <jats:italic>Plasmodium<\/jats:italic>\n            development and subsequent transmission by the\n            <jats:italic>Anopheles<\/jats:italic>\n            mosquito through secretion of a small-molecule inhibitor. We have identified this inhibitor to be the hydrophobic molecule harmane. We also found that, on mosquito contact, harmane penetrates the cuticle, inhibiting\n            <jats:italic>Plasmodium<\/jats:italic>\n            development.\n            <jats:italic>D. tsuruhatensis<\/jats:italic>\n            TC1 stably populates the mosquito gut, does not impose a fitness cost on the mosquito, and inhibits\n            <jats:italic>Plasmodium<\/jats:italic>\n            development for the mosquito\u2019s life. Contained field studies in Burkina Faso and modeling showed that\n            <jats:italic>D. tsuruhatensis<\/jats:italic>\n            TC1 has the potential to complement mosquito-targeted malaria transmission control.\n          <\/jats:p>","DOI":"10.1126\/science.adf8141","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:58:51Z","timestamp":1691085531000},"page":"533-540","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":68,"title":["<i>Delftia tsuruhatensis<\/i>\n            TC1 symbiont suppresses malaria transmission by anopheline mosquitoes"],"prefix":"10.1126","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-7470","authenticated-orcid":true,"given":"Wei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, 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Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-1733","authenticated-orcid":true,"given":"Joseph D.","family":"Challenger","sequence":"additional","affiliation":[{"name":"MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"De Cozar-Gallardo","sequence":"additional","affiliation":[{"name":"Global Health Medicines R&amp;D, GSK, Tres Cantos, 28760 Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-688X","authenticated-orcid":true,"given":"Ignacio","family":"P\u00e9rez-Victoria","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, 18016 Armilla, Granada, 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Sales","family":"Hien","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sciences de la Sant\u00e9 (IRSS), Bobo-Dioulasso BP: 545, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Konkobo","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sciences de la Sant\u00e9 (IRSS), Bobo-Dioulasso BP: 545, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Urones","sequence":"additional","affiliation":[{"name":"Global Health Medicines R&amp;D, GSK, Tres Cantos, 28760 Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Coppens","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, 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