{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:12:36Z","timestamp":1792033956789,"version":"4.4.0"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6665","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2023,9,29]]},"abstract":"<jats:p>\n            <jats:italic>Candida auris<\/jats:italic>\n            is an emerging fungal pathogen responsible for health care\u2013associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by\n            <jats:italic>C. auris<\/jats:italic>\n            and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts.\n            <jats:italic>SCF1<\/jats:italic>\n            is apparently specific to\n            <jats:italic>C. auris<\/jats:italic>\n            , and its expression mediates adhesion to inert and biological surfaces across isolates from all five clades. Unlike canonical fungal adhesins, which function through hydrophobic interactions, Scf1 relies on exposed cationic residues for surface association.\n            <jats:italic>SCF1<\/jats:italic>\n            is required for\n            <jats:italic>C. auris<\/jats:italic>\n            biofilm formation, skin colonization, virulence in systemic infection, and colonization of inserted medical devices.\n          <\/jats:p>","DOI":"10.1126\/science.adf8972","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T18:11:55Z","timestamp":1695924715000},"page":"1461-1467","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":152,"title":["A\n            <i>Candida auris<\/i>\n            \u2013specific adhesin, Scf1\n            <i>,<\/i>\n            governs surface association, colonization, and virulence"],"prefix":"10.1126","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-8352","authenticated-orcid":true,"given":"Darian J.","family":"Santana","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA."},{"name":"Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet A. E.","family":"Anku","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA."},{"name":"West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Accra, Ghana."},{"name":"Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-0704","authenticated-orcid":true,"given":"Guolei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-1500","authenticated-orcid":true,"given":"Robert","family":"Zarnowski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin, Madison, WI, USA."},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin, Madison, WI, USA."},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-0994","authenticated-orcid":true,"given":"Haley","family":"Hautau","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, The Lundquist Institute for Biomedical Innovation at Harbor\u2013University of California, Los Angeles Medical Center, Torrance, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-6020","authenticated-orcid":true,"given":"Noelle D.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-8530","authenticated-orcid":true,"given":"Ashraf S.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, The Lundquist Institute for Biomedical Innovation at Harbor\u2013University of California, Los Angeles Medical Center, Torrance, CA, USA."},{"name":"David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-9950","authenticated-orcid":true,"given":"David","family":"Andes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin, Madison, WI, USA."},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-6244","authenticated-orcid":true,"given":"Jeniel E.","family":"Nett","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin, Madison, WI, USA."},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-0998","authenticated-orcid":true,"given":"Shakti","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, The Lundquist Institute for Biomedical Innovation at Harbor\u2013University of California, Los Angeles Medical Center, Torrance, CA, USA."},{"name":"David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-0154","authenticated-orcid":true,"given":"Teresa R.","family":"O\u2019Meara","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001318"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011268"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020176"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30597-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02252-20"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6544e1"},{"key":"e_1_3_2_8_2","unstructured":"World Health Organization \u201cWHO fungal priority pathogens list to guide research development and public health action\u201d (WHO 2022); 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