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In this work, we describe strategies for HER-coupled enantioselective aryl carbon-hydrogen bond (C\u2013H) activation reactions using cobalt in place of a precious metal catalyst for the asymmetric oxidation. Thus, highly enantioselective carbon-hydrogen and nitrogen-hydrogen (C\u2013H and N\u2013H) annulations of carboxylic amides were achieved, which gave access to point and axially chiral compounds. Furthermore, the cobalt-mediated electrocatalysis enabled the preparation of various phosphorus (P)\u2013stereogenic compounds by selective desymmetrization through dehydrogenative C\u2013H activation reactions.<\/jats:p>","DOI":"10.1126\/science.adg2866","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T09:22:11Z","timestamp":1680081731000},"page":"1036-1042","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":300,"title":["Enantioselective electrochemical cobalt-catalyzed aryl C\u2013H activation reactions"],"prefix":"10.1126","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-6733","authenticated-orcid":true,"given":"Tristan","family":"von M\u00fcnchow","sequence":"first","affiliation":[{"name":"W\u00f6hler Research Institute for Sustainable Chemistry, Georg-August-Universit\u00e4t G\u00f6ttingen, 37077 G\u00f6ttingen, 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