{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:55:17Z","timestamp":1791413717260,"version":"4.3.3"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6639","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>\n                    The Wacker process, which is widely used to convert monosubstituted alkenes into the corresponding methyl ketones, is thought to proceed through a Pd\n                    <jats:sup>II<\/jats:sup>\n                    \/Pd\n                    <jats:sup>0<\/jats:sup>\n                    catalytic cycle involving a \u03b2-hydride elimination step. This mechanistic scenario is inapplicable to the synthesis of ketones from the 1,1-disubstituted alkenes. Current approaches based on\n                    <jats:italic>semi<\/jats:italic>\n                    -pinacol rearrangement of Pd\n                    <jats:sup>II<\/jats:sup>\n                    intermediates are limited to the ring expansion of highly strained methylene cyclobutane derivatives. Herein, we report a solution to this synthetic challenge by designing a Pd\n                    <jats:sup>II<\/jats:sup>\n                    \/Pd\n                    <jats:sup>IV<\/jats:sup>\n                    catalytic cycle incorporating a 1,2-alkyl\/Pd\n                    <jats:sup>IV<\/jats:sup>\n                    dyotropic rearrangement as a key step. This reaction, compatible with a broad range of functional groups, is applicable to both linear olefins and methylene cycloalkanes, including macrocycles. Regioselectivity favors the migration of the more substituted carbon, and a strong directing effect of the \u03b2-carboxyl group was also observed.\n                  <\/jats:p>","DOI":"10.1126\/science.adg3182","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T15:59:10Z","timestamp":1680278350000},"page":"1363-1368","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":69,"title":["Oxidative rearrangement of 1,1-disubstituted alkenes to ketones"],"prefix":"10.1126","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-0451","authenticated-orcid":true,"given":"Qiang","family":"Feng","sequence":"first","affiliation":[{"name":"Laboratory of Synthesis and Natural Products (LSPN), Institute of Chemical Sciences and Engineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-SB-ISIC-LSPN, BCH5304, CH-1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-8644","authenticated-orcid":true,"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis and Natural Products (LSPN), Institute of Chemical Sciences and Engineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-SB-ISIC-LSPN, BCH5304, CH-1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-6689","authenticated-orcid":true,"given":"Jieping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis and Natural Products (LSPN), Institute of Chemical Sciences and Engineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL-SB-ISIC-LSPN, BCH5304, CH-1015 Lausanne, 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