{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:46:52Z","timestamp":1792036012604,"version":"4.4.0"},"reference-count":103,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6680","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2024,1,19]]},"abstract":"<jats:p>Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis of &gt;6500 proteins in 268 longitudinal samples revealed dysregulated activation of the complement system, an innate immune protection and homeostasis mechanism, in individuals experiencing Long Covid. Thus, active Long Covid was characterized by terminal complement system dysregulation and ongoing activation of the alternative and classical complement pathways, the latter associated with increased antibody titers against several herpesviruses possibly stimulating this pathway. Moreover, markers of hemolysis, tissue injury, platelet activation, and monocyte\u2013platelet aggregates were increased in Long Covid. Machine learning confirmed complement and thromboinflammatory proteins as top biomarkers, warranting diagnostic and therapeutic interrogation of these systems.<\/jats:p>","DOI":"10.1126\/science.adg7942","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T13:59:12Z","timestamp":1705586352000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":423,"title":["Persistent complement dysregulation with signs of thromboinflammation in active Long Covid"],"prefix":"10.1126","volume":"383","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7120-8739","authenticated-orcid":true,"given":"Carlo","family":"Cervia-Hasler","sequence":"first","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-1032","authenticated-orcid":true,"given":"Sarah C.","family":"Br\u00fcningk","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland."},{"name":"Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-6064","authenticated-orcid":true,"given":"Tobias","family":"Hoch","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland."},{"name":"Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-2030","authenticated-orcid":true,"given":"Giulia","family":"Muzio","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland."},{"name":"Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-8181","authenticated-orcid":true,"given":"Ryan C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7117-0335","authenticated-orcid":true,"given":"Laura","family":"Ceglarek","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6921-825X","authenticated-orcid":true,"given":"Roman","family":"Meledin","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-6140","authenticated-orcid":true,"given":"Patrick","family":"Westermann","sequence":"additional","affiliation":[{"name":"Precision Proteomics Center, Swiss Institute of Allergy and Asthma Research, University of Zurich, 7265 Davos, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-8811","authenticated-orcid":true,"given":"Marc","family":"Emmenegger","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-7629","authenticated-orcid":true,"given":"Patrick","family":"Taeschler","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-9950","authenticated-orcid":true,"given":"Yves","family":"Zurbuchen","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5290-9172","authenticated-orcid":true,"given":"Michele","family":"Pons","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-1846","authenticated-orcid":true,"given":"Dominik","family":"Menges","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-8600","authenticated-orcid":true,"given":"Tala","family":"Ballouz","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-9090","authenticated-orcid":true,"given":"Sara","family":"Cervia-Hasler","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-3156","authenticated-orcid":true,"given":"Sarah","family":"Adamo","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-7827","authenticated-orcid":true,"given":"Miriam","family":"Merad","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-6858","authenticated-orcid":true,"given":"Alexander W.","family":"Charney","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo","family":"Puhan","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-0046","authenticated-orcid":true,"given":"Petter","family":"Brodin","sequence":"additional","affiliation":[{"name":"Unit for Clinical Pediatrics, Department of Women\u2019s and Children\u2019s Health, Karolinska Institute, 17165 Solna, Sweden."},{"name":"Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5091-8133","authenticated-orcid":true,"given":"Jakob","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-6708","authenticated-orcid":true,"given":"Adriano","family":"Aguzzi","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-0246","authenticated-orcid":true,"given":"Miro E.","family":"Raeber","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7217-0867","authenticated-orcid":true,"given":"Christoph B.","family":"Messner","sequence":"additional","affiliation":[{"name":"Precision Proteomics Center, Swiss Institute of Allergy and Asthma Research, University of Zurich, 7265 Davos, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4258-1574","authenticated-orcid":true,"given":"Noam D.","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."},{"name":"Division of Data Driven and Digital Medicine (D3M), Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-2393","authenticated-orcid":true,"given":"Karsten","family":"Borgwardt","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland."},{"name":"Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8279-5545","authenticated-orcid":true,"given":"Onur","family":"Boyman","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland."},{"name":"Faculty of Medicine and Faculty of Science, University of Zurich, 8006 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"World Health Organization COVID-19 Clinical management: interim guidance 27 May 2020 (World Health Organization 2020); https:\/\/apps.who.int\/iris\/handle\/10665\/332196.","DOI":"10.15557\/PiMR.2020.0004"},{"key":"e_1_3_2_3_2","unstructured":"World Health Organization A clinical case definition of post COVID-19 condition by a Delphi consensus 6 October 2021 (World Health Organization 2021); https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.18931"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0254523"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n136"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32507-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100166"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14364"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.040"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04280-x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01497-y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27797-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.028"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02107-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-00357-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm8108"},{"key":"e_1_3_2_19_2","unstructured":"World Health Organization COVID-19 Clinical management: living guidance 25 January 2021 (World Health Organization 2021); https:\/\/iris.who.int\/bitstream\/handle\/10665\/338882\/WHO-2019-nCoV-clinical-2021.1-eng.pdf."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00986-w"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25509-3"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15302"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00127-8"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15372"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01433-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1028"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1034-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2206346"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb05656.x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01263.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-146472"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abh2259"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1419"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412080"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(89)80054-X"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15052"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(00)00048-7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.70"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-882993"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283564"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2302073"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00586-1"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01298"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.684920"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2515"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.220624"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-769000"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02457-9"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1674-8301(11)60036-5"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35638-y"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01445-w"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.014"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60642-3"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-021-03619-8"},{"key":"e_1_3_2_56_2","unstructured":"Office for National Statistics Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 1 June 2022 Statistical Bulletin (2022); https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/conditionsanddiseases\/bulletins\/prevalenceofongoingsymptomsfollowingcoronaviruscovid19infectionintheuk\/1june2022."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1159\/000082364"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9060143"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.010"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00429-3"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0400-0"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00187"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i3.206"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01114-w"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1713"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00832-x"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01113-x"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00665-1"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg0833"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.add4297"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.861703"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080957"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac151"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.10.013"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01359-7"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01689-3"},{"key":"e_1_3_2_77_2","first-page":"2526","article-title":"Acute respiratory distress syndrome: The Berlin Definition","volume":"307","author":"ARDS Definition Task Force","year":"2012","unstructured":"ARDS Definition Task Force, Acute respiratory distress syndrome: The Berlin Definition. JAMA 307, 2526\u20132533 (2012). 22797452","journal-title":"JAMA"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0175-2"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0665-2"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.105928"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00412"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0392-8"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6485"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2018.02.010"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.047"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"e_1_3_2_91_2","unstructured":"Satija Lab PBMC CITE-seq reference version 1.0.0 Zenodo (2023); https:\/\/doi.org\/10.5281\/zenodo.7779017."},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_2_93_2","doi-asserted-by":"crossref","unstructured":"G. Korotkevich V. Sukhov N. Budin B. Shpak M. N. Artyomov A. Sergushichev Fast gene set enrichment analysis. bioRxiv 060012 [Preprint] (2016); https:\/\/doi.org\/10.1101\/060012.","DOI":"10.1101\/060012"},{"key":"e_1_3_2_94_2","first-page":"2825","article-title":"Scikit-learn: Machine learning in Python","volume":"12","author":"Pedregosa F.","year":"2011","unstructured":"F. Pedregosa, G. Varoquaux, A. Gramfort, V. Michel, B. Thirion, O. Grisel, M. Blondel, P. Prettenhofer, R. Weiss, V. Dubourg, J. Vanderplas, A. Passos, D. Cournapeau, M. Brucher, M. Perrot, \u00c9. Duchesnay, Scikit-learn: Machine learning in Python. J. Mach. Learn. Res. 12, 2825\u20132830 (2011).","journal-title":"J. Mach. Learn. Res."},{"key":"e_1_3_2_95_2","unstructured":"S. M. Lundberg S.-I. Lee A unified approach to interpreting model predictions. arXiv:1705.07874 [cs.AI] (2017)."},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1198\/000313002533"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_3_2_100_2","doi-asserted-by":"crossref","unstructured":"S. Seabold J. Perktold \u201cStatsmodels: Econometric and Statistical Modeling with Python \u201d SciPy 2010 9th Python in Science Conference Austin Texas 28 to 30 June 2010 pp. 92\u201396; https:\/\/doi.org\/10.25080\/Majora-92bf1922-011.","DOI":"10.25080\/Majora-92bf1922-011"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_2_102_2","unstructured":"C. Cervia-Hasler S. Brueningk T. Hoch Persistent complement dysregulation with signs of thrombo-inflammation in active Long Covid version 1 Mendeley Data (2024); https:\/\/doi.org\/10.17632\/dvf6yvrg4x.1."},{"key":"e_1_3_2_103_2","unstructured":"S. Brueningk BorgwardtLab\/LongCOVID: First Release version v0 Zenodo (2023); https:\/\/doi.org\/10.5281\/zenodo.10022438."},{"key":"e_1_3_2_104_2","unstructured":"Mount Sinai COVID-19 Biobank data Synapse (2022); https:\/\/www.synapse.org\/#!Synapse:syn35874390\/."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adg7942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T13:59:42Z","timestamp":1705586382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adg7942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,19]]},"references-count":103,"journal-issue":{"issue":"6680","published-print":{"date-parts":[[2024,1,19]]}},"alternative-id":["10.1126\/science.adg7942"],"URL":"https:\/\/doi.org\/10.1126\/science.adg7942","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,19]]},"assertion":[{"value":"2023-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadg7942"}}