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This subset was disproportionately diminished and dysregulated in inflammatory bowel disease, whereas on-treatment CD103\n            <jats:sup>+<\/jats:sup>\n            \u03b3\u03b4 T cell restoration was associated with sustained inflammatory bowel disease remission. Moreover, CD103\n            <jats:sup>+<\/jats:sup>\n            V\u03b34\n            <jats:sup>+<\/jats:sup>\n            cell dysregulation and loss were also displayed by humans with germline BTNL3\/BTNL8 hypomorphism, which we identified as a risk factor for penetrating Crohn\u2019s disease (CD). Thus, BTNL-dependent selection and\/or maintenance of distinct tissue-intrinsic \u03b3\u03b4 T cells appears to be an evolutionarily conserved axis limiting the progression of a complex, multifactorial, tissue-damaging disease of increasing global incidence.\n          <\/jats:p>","DOI":"10.1126\/science.adh0301","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:58:58Z","timestamp":1694714338000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":81,"title":["Conserved \u03b3\u03b4 T cell selection by BTNL proteins limits progression of human inflammatory bowel disease"],"prefix":"10.1126","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3470-8210","authenticated-orcid":true,"given":"Robin J.","family":"Dart","sequence":"first","affiliation":[{"name":"Peter Gorer Department of Immunobiology, King\u2019s College London at Guy\u2019s Hospital Campus, London, UK."},{"name":"Immunosurveillance Laboratory, The Francis Crick Institute, London, UK."},{"name":"Department of Gastroenterology, Guy\u2019s and St Thomas\u2019 Foundation Trust, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-8042","authenticated-orcid":true,"given":"Iva","family":"Zlatareva","sequence":"additional","affiliation":[{"name":"Peter Gorer Department of Immunobiology, King\u2019s College London at Guy\u2019s Hospital Campus, London, UK."},{"name":"Immunosurveillance Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-5517","authenticated-orcid":true,"given":"Pierre","family":"Vantourout","sequence":"additional","affiliation":[{"name":"Peter Gorer Department of Immunobiology, King\u2019s College London at Guy\u2019s Hospital Campus, London, UK."},{"name":"Immunosurveillance Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Theodoridis","sequence":"additional","affiliation":[{"name":"Peter Gorer Department of Immunobiology, King\u2019s College London at Guy\u2019s Hospital Campus, London, UK."},{"name":"Immunosurveillance Laboratory, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariella","family":"Amar","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, King\u2019s College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichina","family":"Kannambath","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research (NIHR) Biomedical Research Centre (BRC) Genomics Centre, King\u2019s College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5801-5713","authenticated-orcid":true,"given":"Philip","family":"East","sequence":"additional","affiliation":[{"name":"Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6333-4053","authenticated-orcid":true,"given":"Timothy","family":"Recaldin","sequence":"additional","affiliation":[{"name":"GammaDelta Therapeutics Ltd., London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-7750","authenticated-orcid":true,"given":"John C.","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Translational &amp; 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