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Premature thymic eviction is triggered by T cell receptor (TCR)\u2013driven down-regulation of the transcriptional repressor Gfi1, which induces expression of sphingosine-1\u2013phosphate receptor-1 (S1P1) on negatively selected immature CD8 thymocytes. Thus, premature thymic eviction is the basis for CD8 T cell tolerance and is the mechanism responsible for the appearance in the periphery of mature CD8 T cells bearing autoreactive TCRs that are absent from the thymus.<\/jats:p>","DOI":"10.1126\/science.adh4124","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T18:00:04Z","timestamp":1698948004000},"page":"534-541","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":38,"title":["CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus"],"prefix":"10.1126","volume":"382","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-0106","authenticated-orcid":true,"given":"Mohamed Elsherif","family":"Badr","sequence":"first","affiliation":[{"name":"Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, 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