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This process is dependent on BCC engagement with vascular basement membrane laminin through expression of the neuronal pathfinding molecule integrin \u03b16. Once in the LM, BCCs colocalize with perivascular meningeal macrophages and induce their expression of the prosurvival neurotrophin glial-derived neurotrophic factor (GDNF). Intrathecal GDNF blockade, macrophage-specific GDNF ablation, or deletion of the GDNF receptor neural cell adhesion molecule (NCAM) from BCCs inhibits breast cancer growth within the LM. These data suggest integrin \u03b16 and the GDNF signaling axis as new therapeutic targets against breast cancer LM metastasis.<\/jats:p>","DOI":"10.1126\/science.adh5548","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T13:59:48Z","timestamp":1718891988000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":88,"title":["Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis"],"prefix":"10.1126","volume":"384","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-8395","authenticated-orcid":true,"given":"Andrew E.","family":"Whiteley","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC 27710, 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