{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:21:26Z","timestamp":1792092086112,"version":"4.4.0"},"reference-count":72,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6682","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2024,2,2]]},"abstract":"<jats:p>Increasing use of covalent and noncovalent inhibitors of Bruton\u2019s tyrosine kinase (BTK) has elucidated a series of acquired drug-resistant BTK mutations in patients with B cell malignancies. Here we identify inhibitor resistance mutations in BTK with distinct enzymatic activities, including some that impair BTK enzymatic activity while imparting novel protein-protein interactions that sustain B cell receptor (BCR) signaling. Furthermore, we describe a clinical-stage BTK and IKZF1\/3 degrader, NX-2127, that can bind and proteasomally degrade each mutant BTK proteoform, resulting in potent blockade of BCR signaling. Treatment of chronic lymphocytic leukemia with NX-2127 achieves &gt;80% degradation of BTK in patients and demonstrates proof-of-concept therapeutic benefit. These data reveal an oncogenic scaffold function of mutant BTK that confers resistance across clinically approved BTK inhibitors but is overcome by BTK degradation in patients.<\/jats:p>","DOI":"10.1126\/science.adi5798","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T13:58:54Z","timestamp":1706795934000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":177,"title":["Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1\/3 degrader NX-2127"],"prefix":"10.1126","volume":"383","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-6923","authenticated-orcid":true,"given":"Skye","family":"Montoya","sequence":"first","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2499-6064","authenticated-orcid":true,"given":"Jessie","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-1059","authenticated-orcid":true,"given":"Mark","family":"Noviski","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lu","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-4802","authenticated-orcid":true,"given":"Meghan C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5840-4986","authenticated-orcid":true,"given":"Alexandra","family":"Chirino","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-7049","authenticated-orcid":true,"given":"Jacob","family":"Jahn","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-7694","authenticated-orcid":true,"given":"Anya K.","family":"Sondhi","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5432-0403","authenticated-orcid":true,"given":"Stefan","family":"Gajewski","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5417-8088","authenticated-orcid":true,"given":"Ying Siow (May)","family":"Tan","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Yung","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7299-4935","authenticated-orcid":true,"given":"Aleksandra","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway."},{"name":"K.G. Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wang","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-7785","authenticated-orcid":true,"given":"Cuijuan","family":"Han","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-1001","authenticated-orcid":true,"given":"Xiaoli","family":"Mi","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-6119","authenticated-orcid":true,"given":"Won Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-0022","authenticated-orcid":true,"given":"Quinlan","family":"Sievers","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3686-465X","authenticated-orcid":true,"given":"Paul","family":"Auger","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivetha","family":"Brathaban","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Bravo","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Gessner","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Guiducci","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1213-3292","authenticated-orcid":true,"given":"James N.","family":"Iuliano","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2073-8744","authenticated-orcid":true,"given":"Tim","family":"Kane","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6835-3182","authenticated-orcid":true,"given":"Ratul","family":"Mukerji","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-3631","authenticated-orcid":true,"given":"Panga Jaipal","family":"Reddy","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Powers","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Sanchez Garcia de los Rios","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-872X","authenticated-orcid":true,"given":"Jordan","family":"Ye","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-269X","authenticated-orcid":true,"given":"Carla","family":"Barrientos Risso","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-3627","authenticated-orcid":true,"given":"Daniel","family":"Tsai","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Pardo","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-6134","authenticated-orcid":true,"given":"Ryan Q.","family":"Notti","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Pardo","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-6273","authenticated-orcid":true,"given":"Maurizio","family":"Affer","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vindhya","family":"Nawaratne","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4262-4458","authenticated-orcid":true,"given":"Tulasigeri M.","family":"Totiger","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Pena-Velasquez","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-9040","authenticated-orcid":true,"given":"Joanna M.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine at Zucker School of Medicine at Hofstra\/Northwell, CLL Research and Treatment Center, Lake Success, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-6883","authenticated-orcid":true,"given":"Andrew D.","family":"Zelenetz","sequence":"additional","affiliation":[{"name":"Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Alencar","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3806-059X","authenticated-orcid":true,"given":"Lindsey E.","family":"Roeker","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8991-8425","authenticated-orcid":true,"given":"Sanjoy","family":"Mehta","sequence":"additional","affiliation":[{"name":"Gene Editing and Screening Core Facility, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Institute and Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Garippa","sequence":"additional","affiliation":[{"name":"Gene Editing and Screening Core Facility, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Institute and Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-5560","authenticated-orcid":true,"given":"Adam","family":"Linley","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-4358","authenticated-orcid":true,"given":"Rajesh Kumar","family":"Soni","sequence":"additional","affiliation":[{"name":"Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-356X","authenticated-orcid":true,"given":"Sigrid S.","family":"Sk\u00e5nland","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."},{"name":"Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway."},{"name":"K.G. Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-4719","authenticated-orcid":true,"given":"Robert J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"Mato","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2504-5849","authenticated-orcid":true,"given":"Gwenn M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Nurix Therapeutics, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-6171","authenticated-orcid":true,"given":"Omar","family":"Abdel-Wahab","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-6325","authenticated-orcid":true,"given":"Justin","family":"Taylor","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08638"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3702"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-019-00512-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509388"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114110"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.502"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3703"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0178-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211582"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11203287"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01123-6"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11589"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1402716"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400029"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1409"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01049-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0670"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406207221101697"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008325"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-125488"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008447"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00894"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1999.00504.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni890"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5988"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00391"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-862953"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016934"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abg5216"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102555"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1908213"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0161"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr3008495"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4199"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3379"},{"key":"e_1_3_2_37_2","first-page":"186","article-title":"Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer","volume":"9","author":"Zheng C. C.","year":"2019","unstructured":"C. C. Zheng, H. F. Hu, P. Hong, Q. H. Zhang, W. W. Xu, Q. Y. He, B. Li, Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer. Am. J. Cancer Res. 9, 186\u2013197 (2019). 30755822","journal-title":"Am. J. Cancer Res."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b13907"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3207"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0101-6"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031103"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80637-8"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201487900"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015372322419"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-567958"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018891598"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08027-7"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112539"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004826"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814279116"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.09.006"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2000127"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23291"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.040"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0063"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00168"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00217"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_60_2","volume-title":"Ggplot2","author":"Wickham H.","year":"2011","unstructured":"H. Wickham, Ggplot2 (Springer, 2011)."},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.TIR118.000900"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00867"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2834"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr101065j"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909052925"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912001308"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2014.12.006"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3807"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.11.020"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adi5798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T14:02:45Z","timestamp":1706796165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adi5798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":72,"journal-issue":{"issue":"6682","published-print":{"date-parts":[[2024,2,2]]}},"alternative-id":["10.1126\/science.adi5798"],"URL":"https:\/\/doi.org\/10.1126\/science.adi5798","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"2023-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadi5798"}}