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We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and &gt;3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.<\/jats:p>","DOI":"10.1126\/science.adj0070","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:52:44Z","timestamp":1697028764000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":98,"title":["Mapping SARS-CoV-2 antigenic relationships and serological responses"],"prefix":"10.1126","volume":"382","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-8474","authenticated-orcid":true,"given":"Samuel H.","family":"Wilks","sequence":"first","affiliation":[{"name":"Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-8530","authenticated-orcid":true,"given":"Barbara","family":"M\u00fchlemann","sequence":"additional","affiliation":[{"name":"Institute of Virology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany."},{"name":"German Centre for Infection Research (DZIF), partner site Charit\u00e9, 10117 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-3952","authenticated-orcid":true,"given":"Xiaoying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University School of Medicine, Durham, NC, USA."},{"name":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"T\u00fcreli","sequence":"additional","affiliation":[{"name":"Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-5693","authenticated-orcid":true,"given":"Eric B.","family":"LeGresley","sequence":"additional","affiliation":[{"name":"Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-2382","authenticated-orcid":true,"given":"Antonia","family":"Netzl","sequence":"additional","affiliation":[{"name":"Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-9605","authenticated-orcid":true,"given":"Miguela A.","family":"Caniza","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, Department of Infectious Diseases, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-5235","authenticated-orcid":true,"given":"Jesus N.","family":"Chacaltana-Huarcaya","sequence":"additional","affiliation":[{"name":"Hospital Nacional Daniel A. 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