{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:15:03Z","timestamp":1791238503597,"version":"4.1.0"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6707","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2024,7,26]]},"abstract":"<jats:p>\n                    Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1 receptor (GLP-1R) neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMH\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    neurons caused satiation. Calcium imaging demonstrated that these neurons are actively involved in encoding preingestive satiation. GLP-1RA administration increased the activity of DMH\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    neurons selectively during eating behavior. We further identified that an intricate interplay between DMH\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    neurons and neuropeptide Y\/agouti-related peptide neurons of the arcuate nucleus (ARC\n                    <jats:sup>NPY\/AgRP<\/jats:sup>\n                    neurons) occurs to regulate food intake. Our findings reveal a hypothalamic mechanism through which GLP-1RAs control preingestive satiation, offering previously unexplored neural targets for obesity and metabolic diseases.\n                  <\/jats:p>","DOI":"10.1126\/science.adj2537","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T14:07:50Z","timestamp":1719497270000},"page":"438-446","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":156,"title":["GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans"],"prefix":"10.1126","volume":"385","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-8759","authenticated-orcid":true,"given":"Kyu Sik","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-8097","authenticated-orcid":true,"given":"Joon Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-5368","authenticated-orcid":true,"given":"Eunsang","family":"Hwang","sequence":"additional","affiliation":[{"name":"Center for Hypothalamic Research, Department of Internal Medicine, Peter O\u2019Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-3491","authenticated-orcid":true,"given":"Min Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."},{"name":"Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1929-938X","authenticated-orcid":true,"given":"Hwa Yun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-9841","authenticated-orcid":true,"given":"Young Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3609-7441","authenticated-orcid":true,"given":"Laurent","family":"Gautron","sequence":"additional","affiliation":[{"name":"Center for Hypothalamic Research, Department of Internal Medicine, Peter O\u2019Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9719-5048","authenticated-orcid":true,"given":"Elizabeth","family":"Godschall","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Virginia, Charlottesville, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Portillo","sequence":"additional","affiliation":[{"name":"Center for Hypothalamic Research, Department of Internal Medicine, Peter O\u2019Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Grose","sequence":"additional","affiliation":[{"name":"Center for Hypothalamic Research, Department of Internal Medicine, Peter O\u2019Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5886-8855","authenticated-orcid":true,"given":"Sang-Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Lin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-9459","authenticated-orcid":true,"given":"Young Hyun","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4883-0404","authenticated-orcid":true,"given":"Doyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of 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