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We found that in\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    , after a local infection, the conserved cysteine residue of the transcription factor CCA1 HIKING EXPEDITION (CHE) undergoes sulfenylation in systemic tissues, which enhances its binding to the promoter of the SA-synthesis gene\n                    <jats:italic>ISOCHORISMATE SYNTHASE1<\/jats:italic>\n                    (\n                    <jats:italic>ICS1<\/jats:italic>\n                    ) and increases SA production. Furthermore, hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) produced through NADPH oxidases is the mobile signal that sulfenylates CHE in a concentration-dependent manner. Accumulation of SA and the previously reported signal molecules, such as\n                    <jats:italic>N<\/jats:italic>\n                    -hydroxypipecolic acid (NHP), then form a signal amplification loop to establish SAR.\n                  <\/jats:p>","DOI":"10.1126\/science.adj7249","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T14:00:07Z","timestamp":1726149607000},"page":"1211-1217","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":116,"title":["H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    sulfenylates CHE, linking local infection to the establishment of systemic acquired resistance"],"prefix":"10.1126","volume":"385","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7143-5376","authenticated-orcid":true,"given":"Lijun","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Biology, Duke 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