{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:09:37Z","timestamp":1791230977140,"version":"4.1.0"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6729","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,1,3]]},"abstract":"<jats:p>\n                    The recent discovery of nonvisual photoreceptors in various organs has raised expectations for uncovering their roles and underlying mechanisms. In this work, we identified a previously unrecognized hormone-releasing mechanism in the pituitary of the Japanese rice fish (medaka) induced by light. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging analysis revealed that melanotrophs, a type of pituitary endocrine cell that secretes melanocyte-stimulating hormone, robustly increase the concentration of intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    during short-wavelength light exposure. Moreover, we identified Opn5m as the key molecule that drives this response. Knocking out\n                    <jats:italic>opn5m<\/jats:italic>\n                    attenuated melanogenesis by reducing\n                    <jats:italic>tyrosinase<\/jats:italic>\n                    expression in the skin. Our findings suggest a mechanism in which direct reception of short-wavelength light by pituitary melanotrophs triggers a pathway that might contribute to protection from ultraviolet radiation in medaka.\n                  <\/jats:p>","DOI":"10.1126\/science.adj9687","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T13:59:17Z","timestamp":1735826357000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":37,"title":["Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5410-2811","authenticated-orcid":true,"given":"Ayaka","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Marine Bioscience, Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-2951","authenticated-orcid":true,"given":"Keita","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cytology and Histology, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-6277","authenticated-orcid":true,"given":"Chika","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Marine Bioscience, Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-9288","authenticated-orcid":true,"given":"Takahiro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Analytical Laboratory, Kobe Pharmaceutical University, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-606X","authenticated-orcid":true,"given":"Hideyo","family":"Ohuchi","sequence":"additional","affiliation":[{"name":"Department of Cytology and Histology, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-4374","authenticated-orcid":true,"given":"Chie","family":"Umatani","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-1433","authenticated-orcid":true,"given":"Shinji","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Marine Bioscience, Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-100820-094018"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2005-6-3-213"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00997-x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpap.2023.100177"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-animal-020518-115216"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2683-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.15386\/mpr-1235"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076848"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04435.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821099-4.00008-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821099-4.00002-X"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-1879-5_6"},{"key":"e_1_3_2_14_2","volume-title":"Medaka: Biology, Management, and Experimental Protocols","author":"Murata K.","year":"2020","unstructured":"K. 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