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We also report that once-daily oral ODV treatment of cynomolgus monkeys for 10 days beginning 24 hours after SUDV exposure confers 100% protection against lethal infection. Transcriptomics data show that ODV treatment delayed the onset of inflammation and correlated with antigen presentation and lymphocyte activation. Our results offer promise for the further development of ODV to control outbreaks of filovirus disease more rapidly.<\/jats:p>","DOI":"10.1126\/science.adk6176","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T17:58:59Z","timestamp":1710439139000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":48,"title":["Oral administration of obeldesivir protects nonhuman primates against\n            <i>Sudan ebolavirus<\/i>"],"prefix":"10.1126","volume":"383","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-1522","authenticated-orcid":true,"given":"Robert W.","family":"Cross","sequence":"first","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 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