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Combining FOS-Seq, CRISPR-perturbation, and single-nucleus RNA sequencing, we identified\n                    <jats:italic>Rheb<\/jats:italic>\n                    as a molecular substrate that regulates cell type\u2013specific signal transduction in NAc while enabling drugs to suppress natural reward consumption. Mapping NAc-projecting regions activated by drugs of abuse revealed input-specific effects on natural reward consumption. These findings characterize the dynamic, molecular and circuit basis of a common reward pathway, wherein drugs of abuse interfere with the fulfillment of innate needs.\n                  <\/jats:p>","DOI":"10.1126\/science.adk6742","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T13:59:28Z","timestamp":1713448768000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":60,"title":["Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need"],"prefix":"10.1126","volume":"384","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-2881","authenticated-orcid":true,"given":"Bowen","family":"Tan","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, 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