{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:57:25Z","timestamp":1791403045441,"version":"4.3.3"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6723","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:p>Unsymmetrical ureas are commonly found in pharmaceuticals and bioactive compounds. However, devising strategies to introduce two distinct amines selectively in the construction of unsymmetrical ureas remains a challenge. In this work, we use a synchronous recognition strategy that takes advantage of radical and nucleophilic activation to discriminate between secondary and primary amines. Specifically, a copper catalyst preferentially oxidizes secondary amines to radical species, whereas a cobalt catalyst carbonylates primary amines to produce cobalt amides. Coupling these fragments by cooperative catalysis produces unsymmetrical ureas with high selectivity, as showcased by the modification of 41 biologically active compounds and six drugs.<\/jats:p>","DOI":"10.1126\/science.adl0149","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T14:00:03Z","timestamp":1731592803000},"page":"776-782","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":64,"title":["Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas"],"prefix":"10.1126","volume":"386","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9777-8538","authenticated-orcid":true,"given":"Jinhui","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-3404","authenticated-orcid":true,"given":"Shengchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-7908","authenticated-orcid":true,"given":"Zhihong","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Shanxi University, Taiyuan 030006, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-2394","authenticated-orcid":true,"given":"Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-1443","authenticated-orcid":true,"given":"Lin","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8417-3061","authenticated-orcid":true,"given":"Aiwen","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01541"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1MD00058F"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201900058"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0gc00059k"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0494634"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/B612403H"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/b002127j"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo060612n"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05950-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06131-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq1274"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9621"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03448-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-021-00652-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-01023-x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12963"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00512"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07369"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06677"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00115"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00278"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00068"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac60219a014"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/om9509608"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar5002044"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00715"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr300100s"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00532"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar3000019"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00229a003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.11.091"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202200137"},{"key":"e_1_3_2_34_2","unstructured":"A. K. Bjork K. G. Olsson A. L. Abramo E. G. Christensson US Patent 4 385 057 (1983)."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202004560"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9022809"},{"key":"e_1_3_2_37_2","volume-title":"Combustion, Flames and Explosions of Gases","author":"Lewis B.","year":"1987","unstructured":"B. Lewis, G. von Elbe, Combustion, Flames and Explosions of Gases (Elsevier, 1987)."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06568"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja056383o"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7PY01086A"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adl0149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T14:00:58Z","timestamp":1731592858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adl0149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":39,"journal-issue":{"issue":"6723","published-print":{"date-parts":[[2024,11,15]]}},"alternative-id":["10.1126\/science.adl0149"],"URL":"https:\/\/doi.org\/10.1126\/science.adl0149","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,15]]},"assertion":[{"value":"2023-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}