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We generated a super-resolution ribosomal map, revealing subcellular translational hotspots and enrichment of 60\n                    <jats:italic>S<\/jats:italic>\n                    subunits near polysomes at the endoplasmic reticulum (ER). We found that Lsg1 tethers 60\n                    <jats:italic>S<\/jats:italic>\n                    to the ER and regulates translation of select proteins. Additionally, we discovered ribosome heterogeneity at mitochondria guiding translation of metabolism-related transcripts. Lastly, we visualized ribosomes in neurons, revealing a dynamic switch between monosomes and polysomes in neuronal translation. 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