{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:11:18Z","timestamp":1789776678503,"version":"4.0.1"},"reference-count":233,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6730","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,1,10]]},"abstract":"<jats:p>How populations adapt to their environment is a fundamental question in biology.\n                    Yet, we know surprisingly little about this process, especially for endangered\n                    species, such as nonhuman great apes. Chimpanzees, our closest living relatives,\n                    are particularly notable because they inhabit diverse habitats, from rainforest\n                    to woodland-savannah. Whether genetic adaptation facilitates such habitat\n                    diversity remains unknown, despite it having wide implications for evolutionary\n                    biology and conservation. By using newly sequenced exomes from 828 wild\n                    chimpanzees (388 postfiltering), we found evidence of fine-scale genetic\n                    adaptation to habitat, with signatures of positive selection in forest\n                    chimpanzees in the same genes underlying adaptation to malaria in humans. This\n                    work demonstrates the power of noninvasive samples to reveal genetic adaptations\n                    in endangered populations and highlights the importance of adaptive genetic\n                    diversity for chimpanzees.<\/jats:p>","DOI":"10.1126\/science.adn7954","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T13:58:38Z","timestamp":1736431118000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["Local genetic adaptation to habitat in wild                    chimpanzees"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9113-6525","authenticated-orcid":true,"given":"Harrison J.","family":"Ostridge","sequence":"first","affiliation":[{"name":"UCL Genetics Institute, Department of\r                    Genetics, Evolution and Environment, University College London, London,\r                    UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-6026","authenticated-orcid":true,"given":"Claudia","family":"Fontsere","sequence":"additional","affiliation":[{"name":"Center for Evolutionary Hologenomics, The\r                    Globe Institute, University of Copenhagen, Copenhagen, Denmark."},{"name":"Institute of Evolutionary Biology\r                    (UPF-CSIC), PRBB, Dr. Aiguader 88, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3304-9807","authenticated-orcid":true,"given":"Esther","family":"Lizano","sequence":"additional","affiliation":[{"name":"Institute of Evolutionary Biology\r                    (UPF-CSIC), PRBB, Dr. Aiguader 88, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-655X","authenticated-orcid":true,"given":"Daniela C.","family":"Soto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular\r                    Medicine, Genome Center, MIND Institute, University of California, Davis, Davis,\r                    CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-7389","authenticated-orcid":true,"given":"Joshua M.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research\r                    Institute (FHMRI), Department of Ophthalmology, Flinders University Sturt Rd,\r                    Bedford Park, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2329-723X","authenticated-orcid":true,"given":"Vrishti","family":"Saxena","sequence":"additional","affiliation":[{"name":"UCL Genetics Institute, Department of\r                    Genetics, Evolution and Environment, University College London, London,\r                    UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-1092","authenticated-orcid":true,"given":"Marina","family":"Alvarez-Estape","sequence":"additional","affiliation":[{"name":"Institute of Evolutionary Biology\r                    (UPF-CSIC), PRBB, Dr. Aiguader 88, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Barratt","sequence":"additional","affiliation":[{"name":"Naturalis Biodiversity Center, Darwinweg\r                    2, Leiden, the Netherlands."},{"name":"German Centre for Integrative Biodiversity\r                    Research (iDiv) Halle-Leipzig-Jena, Puschstrasse 4, Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-4062","authenticated-orcid":true,"given":"Paolo","family":"Gratton","sequence":"additional","affiliation":[{"name":"University of Rome 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Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-2771","authenticated-orcid":true,"given":"Paula","family":"Dieguez","sequence":"additional","affiliation":[{"name":"Senckenberg Museum for Natural History\r                    G\u00f6rlitz, Senckenberg \u2013 Member of the Leibniz Association, Am\r                    Museum 1, G\u00f6rlitz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Agbor","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Evolutionary\r                    Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7471-3332","authenticated-orcid":true,"given":"Samuel","family":"Angedakin","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Evolutionary\r                    Anthropology (MPI EVAN), Deutscher Platz 6, 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