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Scratching-induced inflammation required pain-sensing nociceptors, the neuropeptide substance P, and the mast cell receptor MrgprB2. Scratching also increased cutaneous inflammation and augmented host defense to superficial\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    infection. Thus, through the activation of nociceptor-driven neuroinflammation, scratching both exacerbated allergic skin disease and provided protection from\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , reconciling the seemingly paradoxical role of scratching as a pathological process and evolutionary adaptation.\n                  <\/jats:p>","DOI":"10.1126\/science.adn9390","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T13:58:37Z","timestamp":1738245517000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":77,"title":["Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-6799","authenticated-orcid":true,"given":"Andrew W.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of 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