{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:44:37Z","timestamp":1792136677134,"version":"4.4.0"},"reference-count":120,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6716","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2024,9,27]]},"abstract":"<jats:p>\n                    The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including Purkinje cells and molecular-layer interneurons, that show different expression of the glutamate ionotropic receptor Delta type subunit 2 (\n                    <jats:italic>GRID2<\/jats:italic>\n                    ) gene. Distinct gene expression profiles were found in anterior, posterior, and vestibular regions in all species, whereas region-selective gene expression was predominantly observed in the granular layer of primates and in the Purkinje layer of mice. Gene expression gradients in the cerebellar cortex matched well with functional connectivity gradients revealed with awake functional magnetic resonance imaging, with more lobule-specific differences between primates and mice than between two primate species. These comprehensive atlases and comparative analyses provide the basis for understanding cerebellar evolution and function.\n                  <\/jats:p>","DOI":"10.1126\/science.ado3927","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T14:00:52Z","timestamp":1727359252000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":60,"title":["Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex"],"prefix":"10.1126","volume":"385","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-3101","authenticated-orcid":true,"given":"Shijie","family":"Hao","sequence":"first","affiliation":[{"name":"BGI Research, Hangzhou 310030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China."},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China."},{"name":"Key Laboratory of Genetic Evolution &amp; Animal Models, Chinese Academy of Sciences, Shanghai, 200031, China."},{"name":"Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2242-0935","authenticated-orcid":true,"given":"Zhi","family":"Huang","sequence":"additional","affiliation":[{"name":"BGI Research, Hangzhou 310030, China."},{"name":"BGI Research, Shenzhen 518083, China."},{"name":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7432-7316","authenticated-orcid":true,"given":"Qianqian","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of 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