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Here we use a degenerate Fermi gas loaded into a three-dimensional optical lattice to study the effect of a tunable Fermi-Hubbard Hamiltonian. The clock laser introduces a spin-orbit coupling spiral phase and breaks the isotropy of superexchange interactions, leading to XXZ-type spin anisotropy. By tuning the lattice confinement and applying imaging spectroscopy, we map out favorable atomic coherence regimes. We transition through various interaction regimes and observe coherent superexchange, tunable through on-site interaction and site-to-site energy shift, affecting the Ramsey fringe contrast over timescales &gt;1 second. This study lays the groundwork for using a three-dimensional optical lattice clock to probe quantum magnetism and spin entanglement.<\/jats:p>","DOI":"10.1126\/science.ado5987","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T21:15:03Z","timestamp":1747775703000},"page":"503-508","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Coherent evolution of superexchange interaction in seconds-long optical clock spectroscopy"],"prefix":"10.1126","volume":"388","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0510-0775","authenticated-orcid":true,"given":"William R.","family":"Milner","sequence":"first","affiliation":[{"name":"JILA, National Institute of Standards and Technology and University of Colorado, Boulder, CO, 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