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We found that a subset of Thetis cells, TC IV, is required for food-specific pT\n            <jats:sub>reg<\/jats:sub>\n            cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes, suggesting that their presence underlies the phenomenon of oral tolerance. A wave of TC IV differentiation in the periweaning period was associated with a window of opportunity for enhanced pT\n            <jats:sub>reg<\/jats:sub>\n            cell generation in response to food antigens. 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