{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:40:04Z","timestamp":1791560404134,"version":"4.3.4"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6778","funder":[{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology: Grants-in-Aid for Scientific Research","award":["19H05650"],"award-info":[{"award-number":["19H05650"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology: Grants-in-Aid for Scientific Research","award":["20H03685"],"award-info":[{"award-number":["20H03685"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology: Grants-in-Aid for Scientific Research","award":["23H02916"],"award-info":[{"award-number":["23H02916"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology: Grant-in-Aid for Young Scientists","award":["19K16683"],"award-info":[{"award-number":["19K16683"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology: Grant-in-Aid for Young Scientists","award":["22K15485"],"award-info":[{"award-number":["22K15485"]}]},{"name":"MSD Life Science Foundation"},{"name":"Ministry of Education, Culture, Sports, Science, and Technology: Transformative Research Areas","award":["21H05120"],"award-info":[{"award-number":["21H05120"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): Practical Research Project for Allergic Diseases and Immunology","award":["21ek0410060h0003"],"award-info":[{"award-number":["21ek0410060h0003"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): AMED-CREST","award":["23gm1210003h0006"],"award-info":[{"award-number":["23gm1210003h0006"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): Research Program on Emerging and Re-emerging Infectious Diseases","award":["JP23fk0210134"],"award-info":[{"award-number":["JP23fk0210134"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): Vaccine Development Support Program","award":["JP243fa627009"],"award-info":[{"award-number":["JP243fa627009"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): Research Program on Emerging and Re-emerging Infectious Diseases","award":["JP24gm1810010"],"award-info":[{"award-number":["JP24gm1810010"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology: Transformative Research Areas","award":["21H05121"],"award-info":[{"award-number":["21H05121"]}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Agency for Medical Research and Development (AMED): Practical Research Project for Allergic Diseases and Immunology","award":["19ek0410045h0003"],"award-info":[{"award-number":["19ek0410045h0003"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): Practical Research Project for Allergic Diseases and Immunology","award":["22ek0410082h0003"],"award-info":[{"award-number":["22ek0410082h0003"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): Practical Research Project for Allergic Diseases and Immunology","award":["24ek0410092h0003"],"award-info":[{"award-number":["24ek0410092h0003"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): AMED-PRIME","award":["20gm6110005h0004"],"award-info":[{"award-number":["20gm6110005h0004"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): AMED-CREST","award":["24gm1810009h0002"],"award-info":[{"award-number":["24gm1810009h0002"]}]},{"name":"Japan Agency for Medical Research and Development (AMED): AMED-SCARDA (Synergy Institute fro Futuristic Mucoasl Vaccine Research and Development","award":["243fa627003h0003"],"award-info":[{"award-number":["243fa627003h0003"]}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"crossref","award":["JPMJFR200R"],"award-info":[{"award-number":["JPMJFR200R"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japan Agency for Medical Research and Development (AMED): AMED-LEAP (Leading Advanced Projects for medical innovation","award":["JP24gm0010011"],"award-info":[{"award-number":["JP24gm0010011"]}]},{"name":"Early-Stage Medical and Pharmaceutical Research Grant, Chiba University Future Medicine Education and Research Organization"},{"name":"Future Medicine Grant Program, Chiba University Future Medicine Fund"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,12,11]]},"abstract":"<jats:p>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    tissue-resident memory T (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) cells contribute to host defense and to the pathogenesis of chronic inflammatory diseases, but the molecules that direct their differentiation are unknown. We found that the transcription factor hepatic leukemia factor (HLF) could direct the tissue residency program and function of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cells. HLF simultaneously up-regulated tissue retention receptors, down-regulated tissue egress receptors, and promoted proinflammatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cells by inducing\n                    <jats:italic toggle=\"yes\">Bhlhe40<\/jats:italic>\n                    , and all of these processes were associated with changes in chromatin accessibility. Genetic deletion of\n                    <jats:italic toggle=\"yes\">Hlf<\/jats:italic>\n                    inhibited CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cell generation and ameliorated airway tissue inflammation in vivo. HLF\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cells isolated from inflamed airway tissue in humans had a tissue residency signature and expressed inflammatory cytokines. We conclude that HLF may act as a central regulator of proinflammatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cell development and function.\n                  <\/jats:p>","DOI":"10.1126\/science.adp0714","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:01:35Z","timestamp":1765479695000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1126","volume":"390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0227-4502","authenticated-orcid":true,"given":"Masahiro","family":"Kiuchi","sequence":"first","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8413-2136","authenticated-orcid":true,"given":"Masahiro","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-9919","authenticated-orcid":true,"given":"Hiroyuki","family":"Yagyu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Department of Pulmonology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-5612","authenticated-orcid":true,"given":"Ami","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Chuo-ku, Niigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3537-8073","authenticated-orcid":true,"given":"Chiaki","family":"Iwamura","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6468-0127","authenticated-orcid":true,"given":"Hikaru","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Predictive Medicine Special Project (PMSP), RIKEN Center for Integrative Medical Sciences (IMS), RIKEN, Yokohama, Kanagawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3515-173X","authenticated-orcid":true,"given":"Yuki","family":"Masuo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan."},{"name":"Kyoto University Immunomonitoring Center (KIC), Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1911-4435","authenticated-orcid":true,"given":"Hajime","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-9448","authenticated-orcid":true,"given":"Shuhe","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan."},{"name":"ASHBi Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3788-1513","authenticated-orcid":true,"given":"Yukiko","family":"Okuno","sequence":"additional","affiliation":[{"name":"Kyoto University Immunomonitoring Center (KIC), Kyoto University, Kyoto, Japan."},{"name":"Medical Research Support Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-8615","authenticated-orcid":true,"given":"Takahisa","family":"Hishiya","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6270-7106","authenticated-orcid":true,"given":"Kaori","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6127-7714","authenticated-orcid":true,"given":"Atsushi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Department of Respirology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-1981","authenticated-orcid":true,"given":"Kota","family":"Kokubo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6194-2632","authenticated-orcid":true,"given":"Kanae","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9831-8399","authenticated-orcid":true,"given":"Rie","family":"Shinmi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Sonobe","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-5520","authenticated-orcid":true,"given":"Tomohisa","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-9072","authenticated-orcid":true,"given":"Syuji","family":"Yonekura","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomasa","family":"Yokomizo","sequence":"additional","affiliation":[{"name":"Microscopic and Developmental Anatomy, Tokyo Women\u2019s Medical University, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Juntendo University Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Onodera","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Institute for Advanced Academic Research, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Research Institute of Disaster Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Okumura","sequence":"additional","affiliation":[{"name":"D ivision of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-8317","authenticated-orcid":true,"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[{"name":"D ivision of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-1918","authenticated-orcid":true,"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[{"name":"D ivision of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-2826","authenticated-orcid":true,"given":"Tatsuaki","family":"Tsuruyama","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-4033","authenticated-orcid":true,"given":"Yosuke","family":"Kurashima","sequence":"additional","affiliation":[{"name":"Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan."},{"name":"Institute for Advanced Academic Research, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Department of Innovative Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Mato","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan."},{"name":"Department of Respirology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-5066","authenticated-orcid":true,"given":"Motoko Yagi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan."},{"name":"Department of Experimental Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Motohashi","sequence":"additional","affiliation":[{"name":"Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-4342","authenticated-orcid":true,"given":"Eiryo","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Predictive Medicine Special Project (PMSP), RIKEN Center for Integrative Medical Sciences (IMS), RIKEN, Yokohama, Kanagawa, Japan."},{"name":"Department of Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-0738","authenticated-orcid":true,"given":"Hideki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan."},{"name":"Kyoto University Immunomonitoring Center (KIC), Kyoto University, Kyoto, Japan."},{"name":"ASHBi Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-857X","authenticated-orcid":true,"given":"Damon J","family":"Tumes","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia."},{"name":"Adelaide University, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-5662","authenticated-orcid":true,"given":"Toyoyuki","family":"Hanazawa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"AMED-CREST, AMED, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-9449","authenticated-orcid":true,"given":"Kiyoshi","family":"Hirahara","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan."},{"name":"Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan."},{"name":"AMED-CREST, AMED, Chuo-ku, Chiba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052350"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-103019-085803"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3031"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053214"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-093019-112809"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13218"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204269120"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02125-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24993"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01229-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.12.007"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2035"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.007"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2745"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13210"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0494-y"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201682"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aas9673"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.013"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.084"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.112"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181399"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009602"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.004"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb6852"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1999-0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05688-9"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.301404"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.043"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.031"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.011"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02284"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.078"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1972"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40156-6"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.09.016"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322292111"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3589"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1386162"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018862383"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2013.07.004"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075011"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1240"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.048"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402256"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00590-3"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01395-9"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06483-w"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq7486"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0298-5"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150568"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.09.002"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.11.044"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.004"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3758"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109682"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.023"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600007"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201690"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2218345120"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giaa151"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.73600.1"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf018"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01282-5"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.044"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0512-6_4"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"},{"key":"e_1_3_2_80_2","first-page":"54","article-title":"Long-term results of non-operative management of ruptured intracranial aneurysms","volume":"19","author":"Mingrino S.","year":"1975","unstructured":"S. Mingrino, G. Salar, M. Scanarini, Long-term results of non-operative management of ruptured intracranial aneurysms. J. Neurosurg. Sci. 19, 54\u201358 (1975). 1221095","journal-title":"J. Neurosurg. Sci."},{"key":"e_1_3_2_81_2","unstructured":"M. Kiuchi M. Nemoto H. Yagyu A. Aoki C. Iwamura H. Sugimoto Y. Masuo H. Morita S. Ma Y. Okuno T. Hishiya K. Tsuji A. Sasaki K. Kokubo K. Ohishi R. Shinmi Y. Sonobe T. Iinuma S. Yonekura T. Yokomizo N. Komatsu A. Onodera S. Okumura T. Ito E. Hatano T. Tsuruyama Y. Kurashima N. Mato T. Suzuki M. Y. Kimura S. Motohashi E. Kawakami H. Ueno D. J. Tumes T. Hanazawa T. Nakayama K. Hirahara Code for: Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells Dryad (2025); https:\/\/doi.org\/10.5061\/dryad.6djh9w1f8."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.adp0714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:02:51Z","timestamp":1765479771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.adp0714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":80,"journal-issue":{"issue":"6778","published-print":{"date-parts":[[2025,12,11]]}},"alternative-id":["10.1126\/science.adp0714"],"URL":"https:\/\/doi.org\/10.1126\/science.adp0714","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"assertion":[{"value":"2024-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadp0714"}}