{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:57:48Z","timestamp":1788411468652,"version":"build-2803163510"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6735","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2025,2,14]]},"abstract":"<jats:p>High sugar\u2013containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the neurobiological mechanisms that underlie the selective appetite for sugar in states of satiety remain unclear. Hypothalamic pro-opiomelanocortin (POMC) neurons are principal regulators of satiety because they decrease food intake through excitatory melanocortin neuropeptides. We discovered that POMC neurons not only promote satiety in fed conditions but concomitantly switch on sugar appetite, which drives overconsumption. POMC neuron projections to the paraventricular thalamus selectively inhibited postsynaptic neurons through mu-opioid receptor signaling. This opioid circuit was strongly activated during sugar consumption, which was most notable in satiety states. Correspondingly, inhibiting its activity diminished high-sugar diet intake in sated mice.<\/jats:p>","DOI":"10.1126\/science.adp1510","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T14:08:56Z","timestamp":1739455736000},"page":"750-758","update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":30,"title":["Thalamic opioids from POMC satiety neurons switch on sugar appetite"],"prefix":"10.1126","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-9771","authenticated-orcid":true,"given":"Marielle","family":"Min\u00e8re","sequence":"first","affiliation":[{"name":"Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, Cologne, Germany."},{"name":"Policlinic for Endocrinology, Diabetes, and Preventive Medicine, University Hospital Cologne, Cologne, 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